Pfam | PF16905 Voltage-dependent L-type calcium channel, IQ-associated

GPHH


Sequence View

The following plot shows contacts with headgroups (magenta), acyl tails (yellow/orange) and solvent (blue) from simulations of 19 protein structures including this sequence. You can choose between showing only consensus values (based on a mean of all structures) and showing data from all structures. If data from all structures is shown, you can click on a residue to view more information.

Secondary structure is also shown using blue for alpha helices and green for beta strands. More conserved residues are indicated by darker coloured areas of secondary structure. Secondary structure which is not conserved in at least 50% of aligned residues is not shown. Domains which are identified through simulation to exist inside the bilayer are indicated by shaded boxes around the secondary structure. The shading of the box indicates the depth within the bilayer, from shallow (red) to deep (yellow).

Alignment of UniProt sequences was carried out using MUSCLE. Displayed sequence is a consensus derived from the alignment.


FCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNVDFDVKAL
102030405060708090100110120

RAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYYIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLT
130140150160170180190200210220230240

VYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVMMLAEEDRNFRRKNRVFRWKCHDLVKSRV
250260270280290300310320330340350360

FYWLVILIVALNTLSIASEHHNQPLWLTHLQDIANRVLLSLFTIEMLLKMYGLGLRQYFMSIFNRFDCFVVCSGILELLLVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLL
370380390400410420430440450460470480

NSIRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSA
490500510520530540550560570580590600

EEEMEEAANQKLALQKAKAVAEERKRRKMSRSVWEQRASQLRLQNLRASVRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRAESVRNQILGYFDIAFTSVFTVEIVLKMTTYGFKL
610620630640650660670680690700710720

HPGKYFRSYFNILDLLVVAVSLISMALSGSKGKDINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFFSCNDLSKMTEEECRGYYYVY
730740750760770780790800810820830840

KDGDPTQMELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYRAIDSNEEDMGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKA
850860870880890900910920930940950960

RPLRRCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHYHQSEEMNHISDILNVAFTIIFTLEMILKLLAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLNFINSAFF
970980990100010101020103010401050106010701080

RLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTN
109011001110112011301140115011601170118011901200

FAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTAL
121012201230124012501260127012801290130013101320

KIKTEGTNFEQADEELRAIIKKIWKRTSMKLLDGLIPPIGP
1330134013501360