PDB | 9b6i Avian great tit TRPM8 channel
Cryo-EM structure of the avian great tit TRPM8 channel in complex with the antagonist TC-I 2014
label Keywords
trpm8, menthol receptor, cold receptor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, trpm8 activation, trpm8 inhibition, trpm8 desensitization, trpm8 antagonists, membrane protein
event_note Published
10/09/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
CALCIUM ION, CHOLESTEROL HEMISUCCINATE, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene
Original publication
import_contacts Title
Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
import_contacts Journal
Sci Adv 2024
import_contacts DOI
10.1126/sciadv.adp2211
person Authors
Lee, S.Y., Suo, Y., Yin, Y., Feng, S., Zhang, F., G Fedor, J., Park, C.G., Im, W.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Lee, S.Y., Suo, Y., Yin, Y., Feng, S., Zhang, F., G Fedor, J., Park, C.G., Im, W. , provided free of copyright via the Protein DataBank. View original data or read license terms.
