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      PDB | 8x52 Human gamma-secretase

      Cryo-EM structure of human gamma-secretase in complex with Abeta49

      label Keywords
      intramembrane protease, gamma-secretase, presenilin-1, membrane protein, membrane protein-hydrolase complex
      event_note Published
      11/06/2024
      filter_center_focus Method
      ELECTRON MICROSCOPY
      add_circle Ligands
      2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL

      Original publication

      import_contacts Title
      Molecular mechanism of substrate recognition and cleavage by human gamma-secretase.
      import_contacts Journal
      Science 2024
      import_contacts DOI
      10.1126/science.adn5820
      person Authors
      Shi, Y., Li, H., Lei, J., Yan, C., Guo, X., Zhou, R.

      Read article from Science

      copyrightData provided by Research Collaboration for Structural Biology, Shi, Y., Li, H., Lei, J., Yan, C., Guo, X., Zhou, R. , provided free of copyright via the Protein DataBank. View original data or read license terms.

      Simulations available

      play_circle_outline8x52_default_dppc

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