PDB | 8w8s AA14-bound GPR101 complex
Cryo-EM structure of the AA14-bound GPR101 complex
label Keywords
gpcr, orphan receptor, gpr101, constitutive activity, cryo-em, structural protein, membrane protein
event_note Published
10/16/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea
Original publication
import_contacts Title
Structure of GPR101-Gs enables identification of ligands with rejuvenating potential.
import_contacts Journal
Nat.Chem.Biol. 2024
import_contacts DOI
10.1038/s41589-023-01456-6
person Authors
Zheng, Y., Guan, Y., Wang, G.P., Zhang, P.J., Ning, S.L., Wang, M.W., Zhu, K.K., Liu, B.H., Yi, F., Yang, F., Zhang, H., Zhou, S.H., Wang, J.Y., Yang, Z., Zhang, C., Yu, X., Xu, F., Xiao, P., Lu, Y., Li, Y., Sun, J.P., Wang, X.W., Gao, N.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Zheng, Y., Guan, Y., Wang, G.P., Zhang, P.J., Ning, S.L., Wang, M.W., Zhu, K.K., Liu, B.H., Yi, F., Yang, F., Zhang, H., Zhou, S.H., Wang, J.Y., Yang, Z., Zhang, C., Yu, X., Xu, F., Xiao, P., Lu, Y., Li, Y., Sun, J.P., Wang, X.W., Gao, N. , provided free of copyright via the Protein DataBank. View original data or read license terms.
