PDB | 8v8a Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596 desensitized intermediate state

Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596 desensitized intermediate state

label Keywords
ion channel, membrane protein, nicotinic receptor
event_note Published
05/14/2025
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
CALCIUM ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, EPIBATIDINE, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea

Original publication

import_contacts Title
Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
import_contacts Journal
Cell 2024
import_contacts DOI
10.1016/j.cell.2024.01.032
person Authors
Noviello, C.M., Avstrikova, M., Cecchini, M., Mukhtasimova, N., Hibbs, R.E., Changeux, J.P., Thakur, G.A., Sine, S.M., Burke, S.M.

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