PDB | 8v6u 5HT2AR-miniGq heterotrimer
5HT2AR-miniGq heterotrimer in complex with a novel agonist obtained from large scale docking
label Keywords
active state gpcr, heterotrimer, complex, serotonin, membrane protein
event_note Published
10/16/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
4-{(3R)-1-[(1R)-1-(pyrimidin-2-yl)ethyl]piperidin-3-yl}phenol
Original publication
import_contacts Title
AlphaFold2 structures guide prospective ligand discovery.
import_contacts Journal
Science 2024
import_contacts DOI
10.1126/science.adn6354
person Authors
Skiniotis, G., Tarkhanova, O.O., Moroz, Y., Kapolka, N., Wang, L., Kim, K., Jain, M.K., Glenn, I.S., Barros-Alvarez, X., Huang, S., Sakamoto, K., Shoichet, B.K., Kruse, A.C., DiBerto, J., Alon, A., Lyu, J., Gumpper, R., Tummino, T.A., Roth, B.L., Irwin, J.J., Kim, Y.
copyrightData provided by Research Collaboration for Structural Biology, Skiniotis, G., Tarkhanova, O.O., Moroz, Y., Kapolka, N., Wang, L., Kim, K., Jain, M.K., Glenn, I.S., Barros-Alvarez, X., Huang, S., Sakamoto, K., Shoichet, B.K., Kruse, A.C., DiBerto, J., Alon, A., Lyu, J., Gumpper, R., Tummino, T.A., Roth, B.L., Irwin, J.J., Kim, Y. , provided free of copyright via the Protein DataBank. View original data or read license terms.
