PDB | 8utb Alpha7-nicotinic acetylcholine receptor bound to epibatidine and NS-1738

Alpha7-nicotinic acetylcholine receptor bound to epibatidine and NS-1738

label Keywords
ion channel, modulator, pam, membrane protein
event_note Published
05/14/2025
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea, 2-acetamido-2-deoxy-beta-D-glucopyranose, EPIBATIDINE, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate

Original publication

import_contacts Title
Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
import_contacts Journal
Cell 2024
import_contacts DOI
10.1016/j.cell.2024.01.032
person Authors
Noviello, C.M., Avstrikova, M., Cecchini, M., Mukhtasimova, N., Hibbs, R.E., Changeux, J.P., Thakur, G.A., Sine, S.M., Burke, S.M.

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