PDB | 8ssb Structure of LBD-TMD of AMPA receptor GluA2

Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state)

label Keywords
ampa receptor, spermidine, tarp gamma-5, cornichon-2, signaling protein
event_note Published
10/16/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, GLUTAMIC ACID, SPERMIDINE

Original publication

import_contacts Title
Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
import_contacts Journal
Nat.Struct.Mol.Biol. 2023
import_contacts DOI
10.1038/s41594-023-01080-x
person Authors
Jones, D.R., Gangwar, S.P., Korman, A., Yelshanskaya, M.V., Yen, L.Y., Sobolevsky, A.I.

Loading