PDB | 8ss3 Structure of LBD-TMD of AMPA receptor GluA2
Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state)
label Keywords
ampa receptor, spermidine, tarp gamma-5, cornichon-2, signaling protein
event_note Published
11/13/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, Digitonin, SPERMIDINE
Original publication
import_contacts Title
Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
import_contacts Journal
Nat.Struct.Mol.Biol. 2023
import_contacts DOI
10.1038/s41594-023-01080-x
person Authors
Jones, D.R., Gangwar, S.P., Korman, A., Yelshanskaya, M.V., Yen, L.Y., Sobolevsky, A.I.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Jones, D.R., Gangwar, S.P., Korman, A., Yelshanskaya, M.V., Yen, L.Y., Sobolevsky, A.I. , provided free of copyright via the Protein DataBank. View original data or read license terms.