PDB | 8ss3 Structure of LBD-TMD of AMPA receptor GluA2

Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state)

label Keywords
ampa receptor, spermidine, tarp gamma-5, cornichon-2, signaling protein
event_note Published
11/13/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, Digitonin, SPERMIDINE

Original publication

import_contacts Title
Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
import_contacts Journal
Nat.Struct.Mol.Biol. 2023
import_contacts DOI
10.1038/s41594-023-01080-x
person Authors
Jones, D.R., Gangwar, S.P., Korman, A., Yelshanskaya, M.V., Yen, L.Y., Sobolevsky, A.I.

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