PDB | 8flm STING oligomer bound to cGAMP, NVS-STG2 and C53

Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53

label Keywords
sting, innate immunity, molecular glue, immune system
event_note Published
03/13/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, cGAMP, 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide

Original publication

import_contacts Title
Activation of human STING by a molecular glue-like compound.
import_contacts Journal
Nat.Chem.Biol. 2024
import_contacts DOI
10.1038/s41589-023-01434-y
person Authors
Nicholson, T.B., Zheng, L., Chen, Y., Mao, X., Tutter, A., McWhirter, S.M., Canham, S.M., Ross, N.T., Henault, M., Cho, C.Y., Wang, Y., Miller, H.R., Michaud, G.A., Feng, Y., Digan, M.E., Sivick, K.E., Hornak, V., Patel, S.J., Pham, H.T., Chen, L., Brittain, S.M., Zhang, X., Schirle, M., Yu, G., Liu, G., Jain, R.K., Jenkins, J.L., Chen, C.H., Broom, W., McKenna, J.M., Tria, G.S., Li, J., Wu, H., Bai, X.C., Tallarico, J.A.

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