PDB | 8fca Human TRPV4 - RhoA
Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate
label Keywords
trpv4, rhoa, 4alpha-phorbol 12, 13-didecanoate, 4a-pdd, membrane protein
event_note Published
06/19/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, CHOLESTEROL HEMISUCCINATE
Original publication
import_contacts Title
TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
import_contacts Journal
Nat Commun 2023
import_contacts DOI
10.1038/s41467-023-39345-0
person Authors
Kumar, M., Sullivan, J.M., Sumner, C.J., Kwon, D.H., McCray, B.A., Feng, S., Lee, S.Y., Zhang, F., Im, W.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Kumar, M., Sullivan, J.M., Sumner, C.J., Kwon, D.H., McCray, B.A., Feng, S., Lee, S.Y., Zhang, F., Im, W. , provided free of copyright via the Protein DataBank. View original data or read license terms.
