PDB | 8e4l The open state mouse TRPM8 structure
The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2
label Keywords
trpm8, menthol receptor, cold receptor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, membrane protein
event_note Published
10/16/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
CALCIUM ION, 3-isothiocyanatoprop-1-ene, nonyl(oxo)di(propan-2-yl)-lambda~5~-phosphane, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Original publication
import_contacts Title
Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
import_contacts Journal
Science 2022
import_contacts DOI
10.1126/science.add1268
person Authors
Borgnia, M.J., Butay, K.J., Yin, Y., Feng, S., Lee, S.Y., Zhang, F., Im, W.
copyrightData provided by Research Collaboration for Structural Biology, Borgnia, M.J., Butay, K.J., Yin, Y., Feng, S., Lee, S.Y., Zhang, F., Im, W. , provided free of copyright via the Protein DataBank. View original data or read license terms.
