PDB | 8ab5 Structure of E. coli GlpG

Structure of E. coli GlpG in complex with peptide derived inhibitor Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl]

label Keywords
rhomboid, protease, glpg, ketoamide, inhibitor, hydrolase
event_note Published
11/13/2024
blur_on Resolution
2.4 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands

Original publication

import_contacts Title
Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency.
import_contacts Journal
Eur.J.Med.Chem. 2024
import_contacts DOI
10.1016/j.ejmech.2024.116606
person Authors
Lepsik, M., Rezac, J., Pecina, A., Fanfrlik, J., Polachova, E., Stanchev, S., Strisovsky, K., Polovinkin, V., Kuzmik, J., Majer, P., Borshchevskiy, V., Bach, K., Dohnalek, J., Skerlova, J.

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