PDB | 7vgj Human P4-type flippase ATP8B1-CDC50A in the auto-inhibited E2Pi-PS state
Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50A in the auto-inhibited E2Pi-PS state
label Keywords
auto-inhibited, phosphorylated, lipid flippase, lipid transport, translocase-lipid transport complex
event_note Published
10/16/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine
Original publication
import_contacts Title
Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding.
import_contacts Journal
Proc.Natl.Acad.Sci.USA 2022
import_contacts DOI
10.1073/pnas.2118656119
person Authors
Chen, Y., Zhang, Z., Hou, W.T., Cheng, M.T., Zhou, C.Z., Chen, Z.P., Liu, X.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Chen, Y., Zhang, Z., Hou, W.T., Cheng, M.T., Zhou, C.Z., Chen, Z.P., Liu, X. , provided free of copyright via the Protein DataBank. View original data or read license terms.
