PDB | 7qne Human full-length synaptic alpha1beta3gamma2 GABA(A)R
Cryo-EM structure of human full-length synaptic alpha1beta3gamma2 GABA(A)R in complex with Ro15-4513 and megabody Mb38
label Keywords
pentameric ligand-gated ion channel, neurotransmitter receptor, gaba receptor, membrane protein
event_note Published
11/06/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, N-OCTANE, DECANE, CHLORIDE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ethyl 8-[(azanylidene-$l^{4}-azanylidene)amino]-5-methyl-6-oxidanylidene-4~{H}-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Original publication
import_contacts Title
Differential assembly diversifies GABA A receptor structures and signalling.
import_contacts Journal
Nature 2022
import_contacts DOI
10.1038/s41586-022-04517-3
person Authors
Zhou, X., Malinauskas, T., Masiulis, S., Chirgadze, D.Y., Hardwick, S.W., Miller, K.W., Aricescu, A.R., Jounaidi, Y., Naydenova, K., Miehling, J., Sente, A., Desai, R.
copyrightData provided by Research Collaboration for Structural Biology, Zhou, X., Malinauskas, T., Masiulis, S., Chirgadze, D.Y., Hardwick, S.W., Miller, K.W., Aricescu, A.R., Jounaidi, Y., Naydenova, K., Miehling, J., Sente, A., Desai, R. , provided free of copyright via the Protein DataBank. View original data or read license terms.
