PDB | 7n3n Human NKCC1 state Fu-I

CryoEM structure of human NKCC1 state Fu-I

label Keywords
sodium, potassium, chloride, co-transporter, ions, human, ctd, tmd, full-length, membrane protein, furosemide, diuretic, loop diuretic
event_note Published
10/30/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID

Original publication

import_contacts Title
Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
import_contacts Journal
Sci Adv 2022
import_contacts DOI
10.1126/sciadv.abq0952
person Authors
Yu, E.W., Su, C.C., Lyu, M., Delpire, E., Moseng, M.A., Cui, M., Rios, K., Klenotic, P.A., Glaza, P.

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