PDB | 6zpl Human glycine transporter 1
Inward-open structure of human glycine transporter 1 in complex with a benzoylisoindoline inhibitor, sybody Sb_GlyT1#7 and bound Na and Cl ions.
label Keywords
secondary active transport, neurotransmitter-sodium symport, amino acid transport, slc6a9, inward open state, inhibitor bound complex, membrane protein
event_note Published
11/13/2024
blur_on Resolution
3.945 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
[5-fluoranyl-6-(oxan-4-yloxy)-1,3-dihydroisoindol-2-yl]-[5-methylsulfonyl-2-[2,2,3,3,3-pentakis(fluoranyl)propoxy]phenyl]methanone, SODIUM ION, CHLORIDE ION
Original publication
import_contacts Title
Structural insights into the inhibition of glycine reuptake.
import_contacts Journal
Nature 2021
import_contacts DOI
10.1038/s41586-021-03274-z
person Authors
Stohler, P., Pinard, E., Guba, W., Shahsavar, A., Siegrist, M., Sinning, S., Dawson, R.J.P., Bourenkov, G., Schneider, T.R., Nissen, P., Seeger, M.A., Zimmermann, I.
copyrightData provided by Research Collaboration for Structural Biology, Stohler, P., Pinard, E., Guba, W., Shahsavar, A., Siegrist, M., Sinning, S., Dawson, R.J.P., Bourenkov, G., Schneider, T.R., Nissen, P., Seeger, M.A., Zimmermann, I. , provided free of copyright via the Protein DataBank. View original data or read license terms.
