PDB | 6r7d Crystal structure of LTC4S in complex with AZ13690257

Crystal structure of LTC4S in complex with AZ13690257

label Keywords
inhibitor, arachidonic acid cascade, cysteinyl leukotrienes, membrane protein
event_note Published
01/24/2024
blur_on Resolution
2.35 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
(1~{S},2~{S})-2-[5-[cyclopropylmethyl(naphthalen-1-yl)amino]-4-methoxy-pyrimidin-2-yl]carbonylcyclopropane-1-carboxylic acid, NICKEL (II) ION, PALMITIC ACID, DODECYL-BETA-D-MALTOSIDE

Original publication

import_contacts Title
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma.
import_contacts Journal
J.Med.Chem. 2019
import_contacts DOI
10.1021/acs.jmedchem.9b00555
person Authors
Bjorkstrand, E., Ripa, L., Munck Af Rosenschold, M., Andersson, U., Kack, H., Ullah, V., Zhou, X.H., Chang, H.F., Jiang, F., Bergstrom, E.L., Tyrchan, C., Swedin, L., Nikitidis, G., Rohman, M., Glader, P., Davis, A.M., Lundqvist, A.J., Malmberg, A., Nikitidis, A., Chapman, D., Ronn, R., Johannesson, P., Pettersen, A., Gordon, E., Ek, M., Andreasson, T., Wagberg, F., Bonn, B.

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