PDB | 6m49 Scap/Insig complex in the present of 25-hydroxyl cholesterol.
cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.
label Keywords
scap, insig, cholesterol, sterol sensing, 25-hydroxycholesterol, srebp, membrane protein
event_note Published
03/27/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
25-HYDROXYCHOLESTEROL
Original publication
import_contacts Title
A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols.
import_contacts Journal
Science 2021
import_contacts DOI
10.1126/science.abb2224
person Authors
Brown, A.J., Yan, R., Coates, H.W., Li, Y., Zhou, Q., Song, W., Qian, H., Cao, P., Gong, X., Yang, H., Lei, J., Sui, J., Gao, S., Zhao, X., Yan, C., Yan, N., Du, X., Liu, X.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Brown, A.J., Yan, R., Coates, H.W., Li, Y., Zhou, Q., Song, W., Qian, H., Cao, P., Gong, X., Yang, H., Lei, J., Sui, J., Gao, S., Zhao, X., Yan, C., Yan, N., Du, X., Liu, X. , provided free of copyright via the Protein DataBank. View original data or read license terms.
