PDB | 5svp Anomalous sulfur signal reveals the position of agonist 2-methylthio-ATP bound to the ATP-gated human P2X3 ion channel in the desensitized state
Anomalous sulfur signal reveals the position of agonist 2-methylthio-ATP bound to the ATP-gated human P2X3 ion channel in the desensitized state
label Keywords
ion channel, desensitized state, anomalous signal, membrane protein
event_note Published
11/20/2024
blur_on Resolution
3.298 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
2-acetamido-2-deoxy-beta-D-glucopyranose, 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate), SODIUM ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE
Original publication
import_contacts Title
X-ray structures define human P2X3 receptor gating cycle and antagonist action.
import_contacts Journal
Nature 2016
import_contacts DOI
10.1038/nature19367
person Authors
Lu, W., Mansoor, S.E., Tajkhorshid, E., Gouaux, E., Shekhar, M., Oosterheert, W.
copyrightData provided by Research Collaboration for Structural Biology, Lu, W., Mansoor, S.E., Tajkhorshid, E., Gouaux, E., Shekhar, M., Oosterheert, W. , provided free of copyright via the Protein DataBank. View original data or read license terms.
