PDB | 5jqh Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60
Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60
label Keywords
gpcr, signaling, nanobody, allostery, signaling protein, hydrolase, hydrolase-inhibitor complex
event_note Published
10/23/2024
blur_on Resolution
3.2 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
(2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, CHOLESTEROL
Original publication
import_contacts Title
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
import_contacts Journal
Nature 2016
import_contacts DOI
10.1038/nature18636
person Authors
Costa, T., Staus, D.P., Lefkowitz, R.J., Ahn, S., Pani, B., Prosser, R.S., Kruse, A.C., Manglik, A., Weis, W.I., Kahsai, A.W., Kim, T.H., Masoudi, A., Wingler, L.M., Steyaert, J., Chatterjee, A., Kobilka, B.K., Strachan, R.T., Pardon, E.
copyrightData provided by Research Collaboration for Structural Biology, Costa, T., Staus, D.P., Lefkowitz, R.J., Ahn, S., Pani, B., Prosser, R.S., Kruse, A.C., Manglik, A., Weis, W.I., Kahsai, A.W., Kim, T.H., Masoudi, A., Wingler, L.M., Steyaert, J., Chatterjee, A., Kobilka, B.K., Strachan, R.T., Pardon, E. , provided free of copyright via the Protein DataBank. View original data or read license terms.
