PDB | 4phu Human GPR40 bound to allosteric agonist TAK-875
Crystal structure of Human GPR40 bound to allosteric agonist TAK-875
label Keywords
gpr40, fatty acid binding protein, class a, g-protein coupled receptor, type ii diabetes, tak-875, fasiglifam, fatty acid binding protein-hydrolase complex
event_note Published
11/06/2024
blur_on Resolution
2.332 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
[(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, PENTAETHYLENE GLYCOL, DIMETHYL SULFOXIDE
Original publication
import_contacts Title
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.
import_contacts Journal
Nature 2014
import_contacts DOI
10.1038/nature13494
person Authors
Jennings, A., Kefala, G., Ivetac, A., Gruswitz, F., Lane, W., Okada, K., Hirozane, Y., Aertgeerts, K., Nguyen, J., Srivastava, A., Snell, G., Yano, J.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Jennings, A., Kefala, G., Ivetac, A., Gruswitz, F., Lane, W., Okada, K., Hirozane, Y., Aertgeerts, K., Nguyen, J., Srivastava, A., Snell, G., Yano, J. , provided free of copyright via the Protein DataBank. View original data or read license terms.
