PDB | 4bpm Human integral membrane enzyme
Crystal structure of a human integral membrane enzyme
label Keywords
isomerase, cancer, drug target, in meso crystallization, inflammation, inhibitor, leukotriene c4 synthase, lipid metabolism, membrane-associated proteins in eicosanoid and glutathione metabolism, mapag, membrane protein, mpges1, pain, microcrystal, anomalous dispersion, sulfur-sad, s-sad
event_note Published
05/08/2024
blur_on Resolution
2.08 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
GLUTATHIONE, 2-[[2,6-bis(chloranyl)-3-[(2,2-dimethylpropanoylamino)methyl]phenyl]amino]-1-methyl-6-(2-methyl-2-oxidanyl-propoxy)-N-[2,2,2-tris(fluoranyl)ethyl]benzimidazole-5-carboxamide
Original publication
import_contacts Title
Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy.
import_contacts Journal
Cryst.Growth Des. 2014
import_contacts DOI
10.1021/CG500157X
person Authors
Edge, C., Hardwicke, P., Bridges, A., Bax, B.D., Dukkipati, A., Wang, M., Shah, S.T.A., Olieric, V., Singh, O.M.P., Giblin, G., Pfau, R., Schnapp, G., Pautsch, A., Li, D., Caffrey, M., Howe, N.
copyrightData provided by Research Collaboration for Structural Biology, Edge, C., Hardwicke, P., Bridges, A., Bax, B.D., Dukkipati, A., Wang, M., Shah, S.T.A., Olieric, V., Singh, O.M.P., Giblin, G., Pfau, R., Schnapp, G., Pautsch, A., Li, D., Caffrey, M., Howe, N. , provided free of copyright via the Protein DataBank. View original data or read license terms.
