PDB | 9f16 Structure of a homomeric LRRC8C point mutation disease mutant
Structure of a homomeric LRRC8C point mutation disease mutant
label Keywords
anion channel, volume regulation, disease mutant, membrane protein
event_note Published
06/04/2025
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
Original publication
import_contacts Title
De novo variants in LRRC8C resulting in constitutive channel activation cause a human multisystem disorder.
import_contacts Journal
Embo J. 2025
import_contacts DOI
10.1038/s44318-024-00322-y
person Authors
Campos-Xavier, B., Superti-Furga, A., Unger, S., Dutzler, R., Barone, A., Quinodoz, M., Garavelli, L., Lehmann, E.F., Rutz, S., Peter, V., Peng, Z., Kellenberger, S., Innes, A.M., Rivolta, C.
copyrightData provided by Research Collaboration for Structural Biology, Campos-Xavier, B., Superti-Furga, A., Unger, S., Dutzler, R., Barone, A., Quinodoz, M., Garavelli, L., Lehmann, E.F., Rutz, S., Peter, V., Peng, Z., Kellenberger, S., Innes, A.M., Rivolta, C. , provided free of copyright via the Protein DataBank. View original data or read license terms.
