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      PDB | 9bqh Full-length human P2X4 receptor in the apo closed state

      Cryo-EM structure of the full-length human P2X4 receptor in the apo closed state

      label Keywords
      membrane protein, ion channel, ligand-gated ion channel, p2x receptor, allosteric antagonist
      event_note Published
      01/29/2025
      filter_center_focus Method
      ELECTRON MICROSCOPY
      add_circle Ligands
      2-acetamido-2-deoxy-beta-D-glucopyranose, DODECYL-BETA-D-MALTOSIDE

      Original publication

      import_contacts Title
      Human P2X4 receptor gating is modulated by a stable cytoplasmic cap and a unique allosteric pocket.
      import_contacts Journal
      Sci Adv 2025
      import_contacts DOI
      10.1126/sciadv.adr3315
      person Authors
      Ditter, I.A., Mansoor, S.E., Oken, A.C., Shi, H.

      Read article from Sci Adv

      Member of

      copyrightData provided by Research Collaboration for Structural Biology, Ditter, I.A., Mansoor, S.E., Oken, A.C., Shi, H. , provided free of copyright via the Protein DataBank. View original data or read license terms.

      Simulations available

      play_circle_outline9bqh_default_dppc

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