PDB | 8xlr Ca2+-bound TMEM16A
Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
label Keywords
inhibitor, modulator, complex, ion channel, lipid binding protein
event_note Published
02/05/2025
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
2-acetamido-2-deoxy-beta-D-glucopyranose, TETRADECANE, CALCIUM ION, Tamsulosin, HEXANE
Original publication
import_contacts Title
Tamsulosin ameliorates bone loss by inhibiting the release of Cl - through wedging into an allosteric site of TMEM16A.
import_contacts Journal
Proc.Natl.Acad.Sci.USA 2025
import_contacts DOI
10.1073/pnas.2407493121
person Authors
Hai, Y., Wang, J., Zheng, Y., He, J., Li, Y., Guo, S., Li, H., Zhao, Z., Ling, S., Zhu, L., Li, J., Zhang, Y., Sun, W., Hu, X., Li, S., Wang, R., Yu, T., Tian, C.
copyrightData provided by Research Collaboration for Structural Biology, Hai, Y., Wang, J., Zheng, Y., He, J., Li, Y., Guo, S., Li, H., Zhao, Z., Ling, S., Zhu, L., Li, J., Zhang, Y., Sun, W., Hu, X., Li, S., Wang, R., Yu, T., Tian, C. , provided free of copyright via the Protein DataBank. View original data or read license terms.
