PDB | 8vpp Phosphorylated human NCC
Phosphorylated human NCC in complex with chlorthalidone
label Keywords
sodium chloride cotransporter, phosphorylation, thiazide-like diuretics, chlorthalidone, transport protein
event_note Published
10/23/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide
Original publication
import_contacts Title
Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases.
import_contacts Journal
Nat Commun 2024
import_contacts DOI
10.1038/s41467-024-51381-y
person Authors
Blakely, A., Rinehart, J., Forbush, B., Smith, M.D., Zhao, Y., Schubert, H., Cao, E.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Blakely, A., Rinehart, J., Forbush, B., Smith, M.D., Zhao, Y., Schubert, H., Cao, E. , provided free of copyright via the Protein DataBank. View original data or read license terms.
