PDB | 8v81 Phosphorylated, ATP-bound, inhibitor 172-bound E1371Q human cystic fibrosis transmembrane conductance regulator
Phosphorylated, ATP-bound, inhibitor 172-bound E1371Q human cystic fibrosis transmembrane conductance regulator
label Keywords
cystic fibrosis, chloride channel, hydrolysis-deficient mutant, membrane protein-inhibitor complex
event_note Published
05/28/2025
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, 4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid
Original publication
import_contacts Title
Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore.
import_contacts Journal
Nat Commun 2024
import_contacts DOI
10.1038/s41467-024-50641-1
person Authors
Kappes, J.C., Jiang, F., Lindahl, E., Gao, X., Yang, Z., Howard, R.J., Hwang, T.C., Yeh, H.I., Fan, C.
copyrightData provided by Research Collaboration for Structural Biology, Kappes, J.C., Jiang, F., Lindahl, E., Gao, X., Yang, Z., Howard, R.J., Hwang, T.C., Yeh, H.I., Fan, C. , provided free of copyright via the Protein DataBank. View original data or read license terms.
