PDB | 8t1e Full-length human TRPV4 in the presence of 4a-PDD
Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD
label Keywords
transient receptor potential v family member 4, trp, channel, trpv4, trp channels, membrane protein, agonist, 4a-pdd, 4alpha-phorbol 12, 13-didecanoate, closed state
event_note Published
10/16/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
[(2~{R})-2-[(~{Z})-hexadec-9-enoyl]oxy-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] (~{Z})-docos-13-enoate, (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION
Original publication
import_contacts Title
Structure of human TRPV4 in complex with GTPase RhoA.
import_contacts Journal
Nat Commun 2023
import_contacts DOI
10.1038/s41467-023-39346-z
person Authors
Nadezhdin, K.D., Parthasarathy, A., Zhang, D.X., Neuberger, A., Sobolevsky, A.I., Talyzina, I.A.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Nadezhdin, K.D., Parthasarathy, A., Zhang, D.X., Neuberger, A., Sobolevsky, A.I., Talyzina, I.A. , provided free of copyright via the Protein DataBank. View original data or read license terms.
