PDB | 8sp8 Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV)
Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV)
label Keywords
phyto-cannabinoid, phytocannabinoid, cannabindoid, tetrahydrocannabivarin, thcv, transient receptor potential v family member 6, trp, human, channel, closed, trpv6, trp channels, cancer, oncochannel, membrane protein, cnw30, nanodiscs, circularized nanodiscs, nanodisc, vanilloid
event_note Published
05/02/2023
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
CHOLESTEROL HEMISUCCINATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Tetrahydrocannabivarin, CALCIUM ION, CHLORIDE ION
Original publication
import_contacts Title
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin.
import_contacts Journal
Nat Commun 2023
import_contacts DOI
10.1038/s41467-023-40362-2
person Authors
Trofimov, Y.A., Nadezhdin, K.D., Krylov, N.A., Neuberger, A., Yelshanskaya, M.V., Sobolevsky, A.I., Khosrof, L.S., Khau, J., Efremov, R.G.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Trofimov, Y.A., Nadezhdin, K.D., Krylov, N.A., Neuberger, A., Yelshanskaya, M.V., Sobolevsky, A.I., Khosrof, L.S., Khau, J., Efremov, R.G. , provided free of copyright via the Protein DataBank. View original data or read license terms.
