PDB | 8qz3 Human two pore domain potassium ion channel TREK-2 (K2P10.1)
Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb67)
label Keywords
potassium ion channel, nanobody, membrane protein, structural genomics, structural genomics consortium, sgc
event_note Published
11/20/2024
blur_on Resolution
2.4 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
POTASSIUM ION, (4S)-2-METHYL-2,4-PENTANEDIOL
Original publication
import_contacts Title
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
import_contacts Journal
Nat Commun 2024
import_contacts DOI
10.1038/s41467-024-48536-2
person Authors
Smith, K.H.M., Baukrowitz, T., Rodstrom, K.E.J., Pike, A.C.W., Tucker, S.J., Newstead, S., Holland-Kaye, I., Bushell, S.R., Elliott, J., Proks, P., Owens, R.J., Cloake, A., Steyaert, J., Schewe, M., Baronina, A., Carpenter, E.P., Ang, J., Sormann, J., Pardon, E.
copyrightData provided by Research Collaboration for Structural Biology, Smith, K.H.M., Baukrowitz, T., Rodstrom, K.E.J., Pike, A.C.W., Tucker, S.J., Newstead, S., Holland-Kaye, I., Bushell, S.R., Elliott, J., Proks, P., Owens, R.J., Cloake, A., Steyaert, J., Schewe, M., Baronina, A., Carpenter, E.P., Ang, J., Sormann, J., Pardon, E. , provided free of copyright via the Protein DataBank. View original data or read license terms.
