PDB | 8pkm Befiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex
Befiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex
label Keywords
membrane protein
event_note Published
07/02/2025
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
CHOLESTEROL, (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, (3-chloranyl-4-fluoranyl-phenyl)-[4-fluoranyl-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
Original publication
import_contacts Title
Discovery of a functionally selective serotonin receptor (5-HT 1A R) agonist for the treatment of pain.
import_contacts Journal
Sci Adv 2025
import_contacts DOI
10.1126/sciadv.adv9267
person Authors
Hove, T., Hubner, H., Inoue, A., Ullrich, A., Basbaum, A.I., Schneider, J., Stanek, M., Bottcher, B., Albert, T., Fink, E., Lober, S., Neu, E., Staffen, N., Weikert, D., Blahova, J., Shoichet, B.K., Braz, J.M., Bhardwaj, K., Gmeiner, P., Allikalt, A., Rasmussen, T., Rodriguez-Rosado, S.
copyrightData provided by Research Collaboration for Structural Biology, Hove, T., Hubner, H., Inoue, A., Ullrich, A., Basbaum, A.I., Schneider, J., Stanek, M., Bottcher, B., Albert, T., Fink, E., Lober, S., Neu, E., Staffen, N., Weikert, D., Blahova, J., Shoichet, B.K., Braz, J.M., Bhardwaj, K., Gmeiner, P., Allikalt, A., Rasmussen, T., Rodriguez-Rosado, S. , provided free of copyright via the Protein DataBank. View original data or read license terms.
