PDB | 8ox9 ATP8B1-CDC50A in E2P active conformation
Cryo-EM structure of ATP8B1-CDC50A in E2P active conformation with bound PC
label Keywords
lipid transporter autoinhibition p-type atpase p4-atpase cdc50a, membrane protein
event_note Published
11/13/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose
Original publication
import_contacts Title
Activation and substrate specificity of the human P4-ATPase ATP8B1.
import_contacts Journal
Nat Commun 2023
import_contacts DOI
10.1038/s41467-023-42828-9
person Authors
Lindorff-Larsen, K., Lyons, J.A., Lenoir, G., Flygaard, R.K., Kummerer, F., Khalid, S., Dieudonne, T., Stock, C., Laursen, M.J., Nissen, P.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Lindorff-Larsen, K., Lyons, J.A., Lenoir, G., Flygaard, R.K., Kummerer, F., Khalid, S., Dieudonne, T., Stock, C., Laursen, M.J., Nissen, P. , provided free of copyright via the Protein DataBank. View original data or read license terms.
