PDB | 8ouo Human TPC2 in Complex with Antagonist (S)-SG-094
Human TPC2 in Complex with Antagonist (S)-SG-094
label Keywords
tpc2, two-pore channel, ion channel, inhibitor, homodimer, metal transport
event_note Published
10/23/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
di-heneicosanoyl phosphatidyl choline, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, (1S)-6-methoxy-2-methyl-7-phenoxy-1-[(4-phenoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, CHOLESTEROL HEMISUCCINATE
Original publication
import_contacts Title
Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist.
import_contacts Journal
Structure 2024
import_contacts DOI
10.1016/j.str.2024.05.005
person Authors
Grimm, C., Bohstedt, T., Jaslan, D., Pike, A.C.W., Chi, G., Krogsaeter, E., Li, H., Keller, M., Bracher, F., Wang, D., Burgess-Brown, N.A., Rautenberg, S., Bock, J., Mukhopadhyay, S.M.M., Fernandez-Cid, A., McKinley, G., Kudrina, V., Durr, K.L.
copyrightData provided by Research Collaboration for Structural Biology, Grimm, C., Bohstedt, T., Jaslan, D., Pike, A.C.W., Chi, G., Krogsaeter, E., Li, H., Keller, M., Bracher, F., Wang, D., Burgess-Brown, N.A., Rautenberg, S., Bock, J., Mukhopadhyay, S.M.M., Fernandez-Cid, A., McKinley, G., Kudrina, V., Durr, K.L. , provided free of copyright via the Protein DataBank. View original data or read license terms.
