PDB | 8kex Gq coupled MRGPRX4
CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local
label Keywords
mrgprx4, bile acid, cholestatic itch, gpcr, agonist, membrane protein
event_note Published
12/25/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
(4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid
Original publication
import_contacts Title
Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch.
import_contacts Journal
Cell 2024
import_contacts DOI
10.1016/j.cell.2024.10.001
person Authors
Yue, Z., Liu, Y., Yu, H., Guo, F., Chen, Y., Li, Y., Lei, X., Shi, Y., Lan, G., Bai, Y., Zou, H., Ke, H., Fan, J., Li, S., Yang, J., Zhao, T., Wang, X.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Yue, Z., Liu, Y., Yu, H., Guo, F., Chen, Y., Li, Y., Lei, X., Shi, Y., Lan, G., Bai, Y., Zou, H., Ke, H., Fan, J., Li, S., Yang, J., Zhao, T., Wang, X. , provided free of copyright via the Protein DataBank. View original data or read license terms.
