PDB | 8im7 Human gamma-secretase treated
Human gamma-secretase treated with ganglioside GM1
label Keywords
intramembrane protease, lipid, ganglioside, gm1, membrane protein
event_note Published
11/06/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL
Original publication
import_contacts Title
Preferential Regulation of Gamma-Secretase-Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease.
import_contacts Journal
Adv Sci 2023
import_contacts DOI
10.1002/advs.202303411
person Authors
Wang, J., Yue, W., Sun, X., Shi, Y., Wang, L., Liu, H., Li, J., Wang, X., Zhang, D., Zhou, R.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Wang, J., Yue, W., Sun, X., Shi, Y., Wang, L., Liu, H., Li, J., Wang, X., Zhang, D., Zhou, R. , provided free of copyright via the Protein DataBank. View original data or read license terms.
