PDB | 8i3v Human norepinephrine transporter NET in the presence of the antidepressant escitalopram in an inward-open st
Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant escitalopram in an inward-open state at resolution of 2.85 angstrom.
label Keywords
norepinephrine, net, escitalopram, inward-open, membrane protein
event_note Published
06/25/2025
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
(1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, CHLORIDE ION
Original publication
import_contacts Title
Molecular basis of human noradrenaline transporter reuptake and inhibition.
import_contacts Journal
Nature 2024
import_contacts DOI
10.1038/s41586-024-07719-z
person Authors
Zhang, X., Xiao, Y., Yuan, Y., Zhu, A., Liu, Y., Lei, J., Tian, B., Yan, C., Tan, J., Xu, H., Kong, F.
copyrightData provided by Research Collaboration for Structural Biology, Zhang, X., Xiao, Y., Yuan, Y., Zhu, A., Liu, Y., Lei, J., Tian, B., Yan, C., Tan, J., Xu, H., Kong, F. , provided free of copyright via the Protein DataBank. View original data or read license terms.
