PDB | 8gqu AK-42 inhibitor binding human ClC-2 TMD
AK-42 inhibitor binding human ClC-2 TMD
label Keywords
homo-dimer, membrane protein
event_note Published
05/08/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid
Original publication
import_contacts Title
Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42.
import_contacts Journal
Nat Commun 2023
import_contacts DOI
10.1038/s41467-023-39218-6
person Authors
Zhang, X., Sun, L., Cui, W., Ma, T., Wang, L., Vogel, H., Li, Z., Zhang, Z., Yan, K., Wing Ngor Au, S., Gao, Y., Wang, D., Zhang, H., Liu, C., Wang, P., Yuan, S., Liang, Y., Wang, Y.T., Chai, A., Lu, J.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Zhang, X., Sun, L., Cui, W., Ma, T., Wang, L., Vogel, H., Li, Z., Zhang, Z., Yan, K., Wing Ngor Au, S., Gao, Y., Wang, D., Zhang, H., Liu, C., Wang, P., Yuan, S., Liang, Y., Wang, Y.T., Chai, A., Lu, J. , provided free of copyright via the Protein DataBank. View original data or read license terms.
