PDB | 8gdb Prostaglandin E2 Receptor 4 Coupled to G Protein
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
label Keywords
gpcr complex, signaling protein
event_note Published
11/13/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid
Original publication
import_contacts Title
Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths.
import_contacts Journal
Proc.Natl.Acad.Sci.USA 2023
import_contacts DOI
10.1073/pnas.2216329120
person Authors
Gan, S., Huang, S.M., Zhang, X., Wang, M.W., Li, S., Liu, Z., Cai, K., Li, Z., Xie, Y., Guo, S.C., Cao, S., Xue, C., Tie, L., Du, Y., Liu, L., Kong, W., Wang, J.L., Wen, X., Yang, Z., Cong, X., Zhang, C., Yang, B.X., Jia, Y.L., Yu, X., Yang, F., Xiong, M.Y., Xiao, P., He, Q.T., Li, Y., Sun, J.P., Mu, J., Qu, C.X., Guan, Y.F., Cai, B.Y.
copyrightData provided by Research Collaboration for Structural Biology, Gan, S., Huang, S.M., Zhang, X., Wang, M.W., Li, S., Liu, Z., Cai, K., Li, Z., Xie, Y., Guo, S.C., Cao, S., Xue, C., Tie, L., Du, Y., Liu, L., Kong, W., Wang, J.L., Wen, X., Yang, Z., Cong, X., Zhang, C., Yang, B.X., Jia, Y.L., Yu, X., Yang, F., Xiong, M.Y., Xiao, P., He, Q.T., Li, Y., Sun, J.P., Mu, J., Qu, C.X., Guan, Y.F., Cai, B.Y. , provided free of copyright via the Protein DataBank. View original data or read license terms.
