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      PDB | 8g1a Cryo-EM structure of Nav1.7 with CBD

      Cryo-EM structure of Nav1.7 with CBD

      label Keywords
      cryo-em, sodium channel, vgsc, nav1.7, cbd, membrane protein
      event_note Published
      10/30/2024
      filter_center_focus Method
      ELECTRON MICROSCOPY
      add_circle Ligands
      2-acetamido-2-deoxy-beta-D-glucopyranose, cannabidiol, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, CHOLESTEROL HEMISUCCINATE, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

      Original publication

      import_contacts Title
      Cannabidiol inhibits Na v channels through two distinct binding sites.
      import_contacts Journal
      Nat Commun 2023
      import_contacts DOI
      10.1038/s41467-023-39307-6
      person Authors
      Huang, J., Jo, S., Jin, X., Fan, X., Bean, B.P., Zhang, H.B., Fujita, A., Yan, N.

      Read article from Nat Commun

      Member of

      copyrightData provided by Research Collaboration for Structural Biology, Huang, J., Jo, S., Jin, X., Fan, X., Bean, B.P., Zhang, H.B., Fujita, A., Yan, N. , provided free of copyright via the Protein DataBank. View original data or read license terms.

      Simulations available

      play_circle_outline8g1a_default_dppc

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