PDB | 8foa Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein

Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein

label Keywords
transient receptor potential v family member 6, trp, human, channel, open, trpv6, inhibitor, blocker, antagonist, genistein, phytoestrogen, isoflavone; trp channels, cancer, oncochannel, natural compound, membrane protein
event_note Published
06/19/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
CHOLESTEROL HEMISUCCINATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ZINC ION, CALCIUM ION, GENISTEIN

Original publication

import_contacts Title
Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.
import_contacts Journal
Nat Commun 2023
import_contacts DOI
10.1038/s41467-023-38352-5
person Authors
Trofimov, Y.A., Nadezhdin, K.D., Krylov, N.A., Neuberger, A., Yelshanskaya, M.V., Sobolevsky, A.I., Efremov, R.G.

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