PDB | 8do3 Human Sec61 complex inhibited by eeyarestatin I

Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin I

label Keywords
translocon, inhibitor, protein translocation, protein transport, protein transport-inhibitor complex
event_note Published
07/12/2022
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea

Original publication

import_contacts Title
A common mechanism of Sec61 translocon inhibition by small molecules.
import_contacts Journal
Nat.Chem.Biol. 2023
import_contacts DOI
10.1038/s41589-023-01337-y
person Authors
Hoepfner, D., Wang, L., Spiess, M., Xiao, L., Shi, W.Q., Junne, T., Park, E., Itskanov, S., Forsyth, C., Sherriff, R., Blanchard, N.

Loading