PDB | 8do0 Human Sec61 complex inhibited by mycolactone
Cryo-EM structure of the human Sec61 complex inhibited by mycolactone
label Keywords
translocon, inhibitor, protein translocation, protein transport, protein transport-inhibitor complex
event_note Published
07/12/2022
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
[(6~{S},7~{S},9~{Z},12~{R})-12-[(~{Z},2~{S},6~{R},7~{R},9~{R})-4,6-dimethyl-7,9-bis(oxidanyl)dec-4-en-2-yl]-7,9-dimethyl-2-oxidanylidene-1-oxacyclododec-9-en-6-yl] (2~{E},4~{E},6~{E},8~{E},10~{E},12~{S},13~{S},15~{S})-4,6,10-trimethyl-12,13,15-tris(oxidanyl)hexadeca-2,4,6,8,10-pentaenoate
Original publication
import_contacts Title
A common mechanism of Sec61 translocon inhibition by small molecules.
import_contacts Journal
Nat.Chem.Biol. 2023
import_contacts DOI
10.1038/s41589-023-01337-y
person Authors
Hoepfner, D., Wang, L., Spiess, M., Xiao, L., Shi, W.Q., Junne, T., Park, E., Itskanov, S., Forsyth, C., Sherriff, R., Blanchard, N.
copyrightData provided by Research Collaboration for Structural Biology, Hoepfner, D., Wang, L., Spiess, M., Xiao, L., Shi, W.Q., Junne, T., Park, E., Itskanov, S., Forsyth, C., Sherriff, R., Blanchard, N. , provided free of copyright via the Protein DataBank. View original data or read license terms.
