PDB | 8cic Stabilized A2A adenosine receptor A2AR-StaR2-bRIL
Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with clinical candidate Etrumadenant
label Keywords
g-protein coupled receptor, signaling protein
event_note Published
10/23/2024
blur_on Resolution
2.102 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
SODIUM ION, 3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, CHOLESTEROL, OLEIC ACID, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Original publication
import_contacts Title
Crystal structure of adenosine A 2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction.
import_contacts Journal
Commun Chem 2023
import_contacts DOI
10.1038/s42004-023-00894-6
person Authors
Cheng, R.K.Y., Strater, N., Weisse, R.H., Schlegel, J.G., Markovic-Mueller, S., Claff, T., Muller, C.E., Vaassen, V.J., Voss, J.H., Bucher, D.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Cheng, R.K.Y., Strater, N., Weisse, R.H., Schlegel, J.G., Markovic-Mueller, S., Claff, T., Muller, C.E., Vaassen, V.J., Voss, J.H., Bucher, D. , provided free of copyright via the Protein DataBank. View original data or read license terms.
