PDB | 7voe Crystal structure of 5-HT2AR in complex with aripiprazole
Crystal structure of 5-HT2AR in complex with aripiprazole
label Keywords
gpcr, dopamine receptor, serotonin receptor, aripiprazole, antipsychotic, membrane protein
event_note Published
11/13/2024
blur_on Resolution
2.9 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
CHOLESTEROL, PENTAETHYLENE GLYCOL, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one, MAGNESIUM ION
Original publication
import_contacts Title
Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties.
import_contacts Journal
Nat.Neurosci. 2022
import_contacts DOI
10.1038/s41593-021-00971-w
person Authors
Chen, Z., Qi, J., Cheng, J., Nie, F., Wang, H., Yu, J., Luo, Z., Lu, D., Liu, Z., Wang, S., Fan, L.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Chen, Z., Qi, J., Cheng, J., Nie, F., Wang, H., Yu, J., Luo, Z., Lu, D., Liu, Z., Wang, S., Fan, L. , provided free of copyright via the Protein DataBank. View original data or read license terms.
