PDB | 7vab Non-acylated tirzepatide (LY3298176)-bound human GIPR-Gs complex
Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GIPR-Gs complex
label Keywords
cryo-electron microscopy; g protein-coupled receptor; ligand recognition; receptor activation; unimolecular agonist, structural protein
event_note Published
08/28/2021
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
CHOLESTEROL
Original publication
import_contacts Title
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
import_contacts Journal
Nat Commun 2022
import_contacts DOI
10.1038/s41467-022-28683-0
person Authors
Chen, Y., Xu, H.E., Wang, M.W., Zou, X., Chen, L.N., Feng, W., Zhao, L., Liang, A., Xia, T., Zhang, Y., Chang, R., Zhang, C., Ming, Q., Dai, A., Wu, B., Cong, Z., Zhao, F., Wang, M., Yang, D., Xu, P., Zhou, Q., Hang, K.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Chen, Y., Xu, H.E., Wang, M.W., Zou, X., Chen, L.N., Feng, W., Zhao, L., Liang, A., Xia, T., Zhang, Y., Chang, R., Zhang, C., Ming, Q., Dai, A., Wu, B., Cong, Z., Zhao, F., Wang, M., Yang, D., Xu, P., Zhou, Q., Hang, K. , provided free of copyright via the Protein DataBank. View original data or read license terms.
