PDB | 7sq9 Mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution
Cryo-EM structure of mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution
label Keywords
ion channel, membrane protein
event_note Published
10/16/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
(2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, (1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30S,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate, SODIUM ION
Original publication
import_contacts Title
Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin.
import_contacts Journal
Proc.Natl.Acad.Sci.USA 2022
import_contacts DOI
10.1073/pnas.2120404119
person Authors
Gan, N., Xue, J., Han, Y., Zeng, W., Wang, Y., Jiang, Y.
copyrightData provided by Research Collaboration for Structural Biology, Gan, N., Xue, J., Han, Y., Zeng, W., Wang, Y., Jiang, Y. , provided free of copyright via the Protein DataBank. View original data or read license terms.
