PDB | 7sim Structure of positive allosteric modulator-free active human calcium-sensing receptor
Structure of positive allosteric modulator-free active human calcium-sensing receptor
label Keywords
calcium-sensing receptor, cryo-em structure, allosteric modulation, activation mechanism, symmetry, membrane protein
event_note Published
11/06/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOMETHYLTRYPTOPHAN, PHOSPHATE ION, CALCIUM ION, CHOLESTEROL
Original publication
import_contacts Title
Symmetric activation and modulation of the human calcium-sensing receptor.
import_contacts Journal
Proc.Natl.Acad.Sci.USA 2021
import_contacts DOI
10.1073/pnas.2115849118
person Authors
Lee, Y., Fan, Q.R., Yen, L.Y., Liu, Z., Kloss, B., Slavkovich, V.N., Liu, J., Grassucci, R., Tan, Y.Z., Conigrave, A.D., Mosyak, L., Hendrickson, W.A., Ray, K.M., Park, J., Carragher, B., Graziano, J., Zuo, H., Zhang, Z., Cao, B., Fu, Z., Geng, Y., Clarke, O.B., Potter, C.S., Frank, J., Eng, E., Chen, S., Frangaj, A., Dandey, V.P., Vallese, F.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Lee, Y., Fan, Q.R., Yen, L.Y., Liu, Z., Kloss, B., Slavkovich, V.N., Liu, J., Grassucci, R., Tan, Y.Z., Conigrave, A.D., Mosyak, L., Hendrickson, W.A., Ray, K.M., Park, J., Carragher, B., Graziano, J., Zuo, H., Zhang, Z., Cao, B., Fu, Z., Geng, Y., Clarke, O.B., Potter, C.S., Frank, J., Eng, E., Chen, S., Frangaj, A., Dandey, V.P., Vallese, F. , provided free of copyright via the Protein DataBank. View original data or read license terms.
