PDB | 7sii Human STING bound to both cGAMP and 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide (Compound 53)
Human STING bound to both cGAMP and 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide (Compound 53)
label Keywords
sting, agonist, activate conformation, oligomer, immune system
event_note Published
06/05/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, cGAMP
Original publication
import_contacts Title
Activation of STING by targeting a pocket in the transmembrane domain.
import_contacts Journal
Nature 2022
import_contacts DOI
10.1038/s41586-022-04559-7
person Authors
Zhang, X., Lu, Y., Shang, G., Lu, D., Li, J., Bai, X.C.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Zhang, X., Lu, Y., Shang, G., Lu, D., Li, J., Bai, X.C. , provided free of copyright via the Protein DataBank. View original data or read license terms.
