PDB | 7s8n Gq-coupled MRGPRX2
CryoEM structure of Gq-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573
label Keywords
gpcr, signaling protein
event_note Published
11/13/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
(3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine
Original publication
import_contacts Title
Structure, function and pharmacology of human itch GPCRs.
import_contacts Journal
Nature 2021
import_contacts DOI
10.1038/s41586-021-04126-6
person Authors
Abraham, S.N., Ye, W., Zhang, S., Roth, B.L., Cao, C., Krumm, B.E., Liu, J., English, J.G., Kang, H.J., Jin, J., Chen, H., Kroeze, W.K., Kim, K., Zhang, C., Jan, L.Y., Liu, Y., McCorvy, J.D., Hayes, B.W., Lansu, K., Huang, X.P., Singh, I., Bender, B.J., Shoichet, B.K., Karpiak, J., Gumpper, R.H., Slocum, S.T., Fay, J.F., DiBerto, J.F., Olsen, R.H.J.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Abraham, S.N., Ye, W., Zhang, S., Roth, B.L., Cao, C., Krumm, B.E., Liu, J., English, J.G., Kang, H.J., Jin, J., Chen, H., Kroeze, W.K., Kim, K., Zhang, C., Jan, L.Y., Liu, Y., McCorvy, J.D., Hayes, B.W., Lansu, K., Huang, X.P., Singh, I., Bender, B.J., Shoichet, B.K., Karpiak, J., Gumpper, R.H., Slocum, S.T., Fay, J.F., DiBerto, J.F., Olsen, R.H.J. , provided free of copyright via the Protein DataBank. View original data or read license terms.
